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Article

Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.

Clinical genetics - 1 Feb 2023

Ariste Olivier, de la Grange Pierre, Veitia Reiner A

Abstract excerpt

Clonal hematopoiesis (CH) consists in an abnormal expansion of a hematopoietic stem cell bearing an advantageous somatic variant. A survey of known recurrent somatic missense variants in DNMT3A, SF3B1, SRSF2, and TP53, some of the most prominent genes underlying CH of indeterminate potential (CHIP), in gnomAD noncancer database shows the presence of 73 variants. Many of them reach frequencies higher than 0.01% in...

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Identifiers

PMID: 36353970
DOI: 10.1111/cge.14259
PMCID: PMC10100246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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