Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site

1 Dec 2015

Abstract excerpt

Influenza-virus antigenicity evolves to escape host immune protection. Antibody lineages within individuals evolve in turn to increase affinity and hence potency. Strategies for a "universal" influenza vaccine to elicit lineages that escape this evolutionary arms race and protect against seasonal variation and novel, pandemic viruses will require directing B cell ontogeny to focus the humoral response on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Influenza Virus Research Studies
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26711348
DOI: 10.1016/j.celrep.2015.11.063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding SitePMID 26711348Read ↗

Antigenic drift expands viral escape pathways from imprinted host humoral immunitySemantic proximity Read ↗

An epitope-enriched immunogen expands responses to a conserved viral siteSemantic proximity Read ↗

Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu virusesSemantic proximity Read ↗

H5N1 Vaccine–Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin StemSemantic proximity Read ↗

Antigenic drift expands influenza viral escape pathways from recalled humoral immunity.Semantic proximity Read ↗

Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving virusesSemantic proximity Read ↗

A hemagglutinin and neuraminidase biased immunological memory shapes the dynamics of antibody responses to Influenza A virusSemantic proximity Read ↗

Imprinting, immunodominance, and other impediments to generating broad influenza immunitySemantic proximity Read ↗

Cellular and Molecular Immunity to Influenza Viruses and VaccinesSemantic proximity Read ↗

Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine ImmunogensSemantic proximity Read ↗

Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stemSemantic proximity Read ↗

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.