A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.

doi:10.1016/j.celrep.2024.114259

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.

Cell reports - 25 Jun 2024

Hulin-Curtis Sarah, Geary James K, MacLachlan Bruce J, Altmann Danny M, Baillon Laury, Cole David K, Greenshields-Watson Alex, Hesketh Sophie J, Humphreys Ian R, Jones Ian M, Lauder Sarah N, Mason Georgina H, Smart Kathryn, Scourfield D Oliver, Scott Jake, Sukhova Ksenia, Stanton Richard J, Wall Aaron, Rizkallah Pierre J, Barclay Wendy S, Gallimore Awen, Godkin Andrew

Abstract excerpt

CD4+ T cells are central to adaptive immunity. Their role in cross-protection in viral infections such as influenza and severe acute respiratory syndrome (SARS) is well documented; however, molecular rules governing T cell receptor (TCR) engagement of peptide-human leukocyte antigen (pHLA) class II are less understood. Here, we exploit an aspect of HLA class II presentation, the peptide-flanking residues (PFRs),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Epitopes

Share to Influenza A virus

Share to Influenza, Human

Share to Lymphocyte Activation

Share to Orthomyxoviridae Infections

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 38819988
DOI: 10.1016/j.celrep.2024.114259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.PMID 38819988Read ↗

Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability.Semantic proximity Read ↗

Molecular basis for universal HLA-A*0201–restricted CD8 <sup>+</sup> T-cell immunity against influenza virusesSemantic proximity Read ↗

An epitope-enriched immunogen expands responses to a conserved viral siteSemantic proximity Read ↗

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.Semantic proximity Read ↗

CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and ageSemantic proximity Read ↗

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humansSemantic proximity Read ↗

Cross-reactive CD4+ T cell responses towards seasonal and avian influenzaSemantic proximity Read ↗

Conservation and Diversity of Influenza A H1N1 HLA-Restricted T Cell Epitope Candidates for Epitope-Based VaccinesSemantic proximity Read ↗

Broad heterologous protection against Influenza A viruses by an adjuvant-free modular mucosal T-cell vaccine platform.Semantic proximity Read ↗

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus InfectionSemantic proximity Read ↗

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensSemantic proximity Read ↗

Broad heterologous protection against Influenza A viruses by an adjuvant-free modular mucosal T-cell vaccine platformSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.