Article

Liquid-liquid phase separation and amyloid aggregation in the 14-3-3 protein family

2026-01-08

Abstract excerpt

The 14-3-3 protein family, with over 1300 binding partners, is one of the largest regulators of protein-protein interactions (PPIs) in eukaryotic cells. They recognise and bind to phosphorylation-related motifs in their partner proteins, creating scaffolds to stabilise proteins and allowing or inhibiting kinases’ access to their targets. 14-3-3 consists of seven isoforms (β, γ, ε, ζ, η, θ and σ), which are express...

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Literature Corpus work: ae835365-6ae4-58e4-8f55-f662406d7933
DOI: 10.64898/2026.01.07.698245

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