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Article

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

8 Nov 2022

Abstract excerpt

Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the complement system as a key component of pathogenesis in AMD, which has been further supported by pre-clinical and recent clinical studies. However, the involvement of the different complement pathways (classical, lectin, alternative), and thus the optimal complement...

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PMID: 36348407
DOI: 10.1186/s40942-022-00431-y

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