Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement cascade inhibition in geographic atrophy: a review.

Eye (London, England) - 1 Feb 2022

Desai Dhaval, Dugel Pravin U

Abstract excerpt

The pathophysiology of dry age-related macular degeneration (AMD) and specifically geographic atrophy (GA) has been linked to the complement cascade. This cascade is part of the innate immune system and is made up of the classical, alternative, and lectin pathways. The pathways comprise a system of plasma and membrane-associated serum proteins that are activated with identification of a nonself entity. A number...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Activation
Share to Complement Factor H
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Geographic Atrophy

Share to Macular Degeneration

Share to Polymorphism, Single Nucleotide

Share to Proteins

Share to Retinal Diseases and Treatments

Source

Open in PubMed Open full text

Identifiers

PMID: 34999723
DOI: 10.1038/s41433-021-01765-x
PMCID: PMC8807727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement cascade inhibition in geographic atrophy: a review.PMID 34999723Read ↗

Therapeutic targeting of the complement system in ocular diseaseSemantic proximity Read ↗

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degenerationSemantic proximity Read ↗

Therapeutic targeting of the complement system in age‐related macular degeneration: a reviewSemantic proximity Read ↗

Complement Inhibitors in Age-Related Macular Degeneration: A Potential Therapeutic Option.Semantic proximity Read ↗

Complement System and Potential Therapeutics in Age-Related Macular DegenerationSemantic proximity Read ↗

Local Complement Inhibition for Geographic Atrophy in Age-Related Macular Degeneration: Prospects, Challenges, and Unanswered QuestionsSemantic proximity Read ↗

Complement system modulation in age-related macular degeneration: navigating failures, building future successesSemantic proximity Read ↗

Complement regulation in the eye: implications for age-related macular degenerationSemantic proximity Read ↗

Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular DegenerationSemantic proximity Read ↗

The roadmap to geographic atrophy treatment: A journey of trials and promiseSemantic proximity Read ↗

Complement in Immune and Inflammatory Disorders: Therapeutic InterventionsSemantic proximity Read ↗

Complement Regulatory Proteins are Associated with Progression Rate of Geographic Atrophy Secondary to Age-related Macular DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.