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Complement system modulation in age-related macular degeneration: navigating failures, building future successes

28 Jul 2025

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in elderly populations across developed countries. Complement system dysregulation has been implicated in AMD onset and evolution. Complement inhibition therapies have been authorized in the USA as the primary treatment for geographic atrophy, the dry form of AMD. They have shown moderate efficacy in slowing geographic...

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PMID: 40729928
DOI: 10.1016/j.coi.2025.102616

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