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Article

Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?

3 Nov 2014

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver of disease. This...

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PMID: 26237601
DOI: 10.3390/jcm3041234

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