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Article

Integrated proteogenomic characterization of medullary thyroid carcinoma

8 Nov 2022

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy derived from parafollicular cells (C cells) of the thyroid. Here we presented a comprehensive multi-omics landscape of 102 MTCs through whole-exome sequencing, RNA sequencing, DNA methylation array, proteomic and phosphoproteomic profiling. Integrated analyses identified BRAF and NF1 as novel driver genes in addition to the well-characterized...

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PMID: 36344509
DOI: 10.1038/s41421-022-00479-y

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