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Article

The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.

BMC cancer - 18 Dec 2015

Kasaian Katayoon, Wiseman Sam M, Walker Blair A, Schein Jacqueline E, Zhao Yongjun, Hirst Martin, Moore Richard A, Mungall Andrew J, Marra Marco A, Jones Steven J M

Abstract excerpt

BACKGROUND: Anaplastic thyroid carcinoma is the most undifferentiated form of thyroid cancer and one of the deadliest of all adult solid malignancies. Here we report the first genomic and transcriptomic profile of anaplastic thyroid cancer including those of several unique cell lines and outline novel potential drivers of malignancy and targets of therapy. METHODS: We describe whole genomic and transcriptomic...

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Source

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Identifiers

PMID: 26680454
DOI: 10.1186/s12885-015-1955-9
PMCID: PMC4683857

Genes

BRAF
SS18
BCL11A
EP300
FGFR2
HDAC10
KIT
MECP2
MKRN1
OGDH
RET
SLC5A11
SMARCA2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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