Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RET Alterations Differentiate Molecular Profile of Medullary Thyroid Cancer.

JCO precision oncology - 1 May 2024

Prabhash Kumar, Saldanha Elveera, Patil Vijay, Bal Munita, Reddy P Sreekanth, Sanjeev Airy, Kumar Raunak, Poojary Disha, Noronha Vanita, Menon Nandini, Mittal Neha, Trivedi Vaishakhi, Nambiar Kavya, Mishra Rohit, Tanwar Nishtha, Malhotra Richa, Pange Priyanka, Gupta Vinod, Veldore Vidya H, Chougule Anuradha, Chaturvedi Pankaj, Dutt Amit, Chandrani Pratik

Abstract excerpt

PURPOSE: Medullary thyroid cancer (MTC) is a rare cancer originating from parafollicular C cells of the thyroid gland. Therapeutically relevant alterations in MTC are predominantly reported in RET oncogene, and lower-frequency alterations are reported in KRAS and BRAF. Nevertheless, there is an unmet need existing to analyze the MTC in the Indian cohort by using in-depth sequencing techniques that go beyond the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Carcinoma, Neuroendocrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HRAS gene

Share to SF3B1 gene

Share to Mutation

Share to Proto-Oncogene Proteins c-ret

Share to Thyroid Neoplasms

Share to Young Adult

Source

Identifiers

PMID: 38754058
DOI: 10.1200/PO.23.00622

Genes

RET
BRAF
KRAS
HRAS
SF3B1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RET Alterations Differentiate Molecular Profile of Medullary Thyroid Cancer.PMID 38754058Read ↗

Medullary Thyroid Carcinoma Mutational Spectrum Update and Signaling-Type Inference by Transcriptional Profiles: Literature Meta-Analysis and Study of Tumor SamplesSemantic proximity Read ↗

Integrated proteogenomic characterization of medullary thyroid carcinomaSemantic proximity Read ↗

Review of Genomic Drivers of Thyroid Cancer and Their Clinical Implications.Semantic proximity Read ↗

The Genomic Landscape of Thyroid Cancer Tumourigenesis and Implications for Immunotherapy.Semantic proximity Read ↗

Molecular Basis and Natural History of Medullary Thyroid Cancer: It is (Almost) All in the RETSemantic proximity Read ↗

Molecular genetics, therapeutics and RET inhibitor resistance for medullary thyroid carcinoma and future perspectivesSemantic proximity Read ↗

Association of the Genomic Profile of Medullary Thyroid Carcinoma with Tumor Characteristics and Clinical Outcomes in an International Multicenter Study.Semantic proximity Read ↗

Medullary Thyroid Cancer: Molecular Biology and Novel Molecular TherapiesSemantic proximity Read ↗

Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy.Semantic proximity Read ↗

Decoding the Mutational Hierarchy of Thyroid Cancer and Associated Signaling Pathways.Semantic proximity Read ↗

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.Semantic proximity Read ↗

Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.