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Article

Proteogenomic characterization delineates clinically relevant subtypes of advanced differentiated thyroid cancer.

Cell reports. Medicine - 17 Mar 2026

Zhang Tingting, Cui Wangpeng, Tang Haitao, Shen Cenkai, Zhang Yan, Sun Yaoting, Zhou Yan, Shen Chentian, Xu Huajun, Wang Chenyi, Ding Wenyang, Zheng Fuxing, Xu Tiansheng, Liu Chuqiao, Du Yuxin, Liu Zhiyan, Wang Yulong, Huang Naisi, Mao Xiaoqi, Ji Dongmei, Sun Xing, Ji Qinghai, Wei Wenjun, Wang Yu, Shi Xiao

Abstract excerpt

Advanced differentiated thyroid cancer (DTC) is characterized by limited therapeutic options and unfavorable prognosis. To address this, we conduct proteogenomic analysis of 113 advanced DTCs, identifying three molecularly distinct subtypes: canonical, stromal, and immunogenic. These subtypes exhibit differences in driver mutations, histopathological features, and clinical outcomes. Based on their unique biology,...

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Identifiers

PMID: 41794039
DOI: 10.1016/j.xcrm.2026.102661
PMCID: PMC13006413

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