Spatially Resolved Molecular Characterization of Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features (NIFTPs) Identifies a Distinct Proteomic Signature Associated with RAS-Mutant Lesions.

doi:10.3390/ijms252313115

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Article

Spatially Resolved Molecular Characterization of Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features (NIFTPs) Identifies a Distinct Proteomic Signature Associated with RAS-Mutant Lesions.

International journal of molecular sciences - 6 Dec 2024

Denti Vanna, Greco Angela, Alviano Antonio Maria, Capitoli Giulia, Monza Nicole, Smith Andrew, Pilla Daniela, Maggioni Alice, Ivanova Mariia, Venetis Konstantinos, Maffini Fausto, Garancini Mattia, Pincelli Angela Ida, Galimberti Stefania, Magni Fulvio, Fusco Nicola, L'Imperio Vincenzo, Pagni Fabio

Abstract excerpt

Follicular-patterned thyroid neoplasms comprise a diverse group of lesions that pose significant challenges in terms of differential diagnosis based solely on morphologic and genetic features. Thus, the identification of easily testable biomarkers complementing microscopic and genetic analyses is a highly anticipated advancement that could improve diagnostic accuracy, particularly for noninvasive follicular...

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PMID: 39684824
DOI: 10.3390/ijms252313115
PMCID: PMC11641690

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