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Article

Comprehensive Transcriptome Profiling of Sporadic Medullary Thyroid Carcinomas.

Scientific data - 15 Jan 2026

Palumbo Domenico, Melone Viola, Palo Luigi, Russo Fabio, Rocco Domenico, Mian Caterina, Barollo Susi, Censi Simona, Bertazza Loris, Zatelli Maria Chiara, Weisz Alessandro, Tarallo Roberta, Vitale Mario

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare thyroid cancer arising from parafollicular C cells belonging to the heterogeneous class of neuroendocrine neoplasms. Mutations in the RET and RAS genes are detected in approximately 50% to 80% of sporadic MTCs, while other genetic alterations are relatively uncommon. Only a few transcriptomic studies of this neoplasia have been performed, and the biology and the...

Topics

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Carcinoma, Neuroendocrine
Gene Expression Profiling
RET gene
Mutation
Thyroid Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41540057
DOI: 10.1038/s41597-026-06550-7
PMCID: PMC12905205

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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