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Article

Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.

Neurobiology of aging - 1 Feb 2022

Kulminski Alexander M, Philipp Ian, Shu Leonardo, Culminskaya Irina

Abstract excerpt

Despite advances, the roles of genetic variants from the APOE-harboring 19q13.32 region in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach to gain insights into a more homogeneous genetic architecture of AD in this region. We use a sample of 2,673 AD-affected and 16,246 unaffected subjects from 4 studies and validate our main findings in the landmark Alzheimer's Disease...

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Identifiers

PMID: 34625307
DOI: 10.1016/j.neurobiolaging.2021.09.009
PMCID: PMC8758518

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