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Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level

2 Nov 2022

Abstract excerpt

Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic integrity. A highly kinked DNA structure in complex with human PARP-1 domains led to the proposal that SSB sensing in Eukaryotes relies on dynamics of both the broken DNA double helix and PARP-1's multi-domain organization. Here, we directly probe this process at the single-molecule level. Quantitative smFRET and structural...

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PMID: 36323657
DOI: 10.1038/s41467-022-34148-1

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