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Article

Cancer-associated TRF1 mutations alter PARP1 interaction dynamics: an in silico study.

Mammalian genome : official journal of the International Mammalian Genome Society - 14 Mar 2026

Mishra Apurwa, Patel Trupti N

Abstract excerpt

Telomeric repeat-binding factor 1 (TRF1), a core component of the shelterin complex, is essential for preserving telomere integrity by facilitating efficient replication fork progression across G-rich telomeric DNA. Through its interaction with poly (ADP-ribose) polymerase 1 (PARP1), TRF1 contributes to telomeric chromatin organization and supports the recruitment of helicases required to resolve...

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Identifiers

PMID: 41832376
DOI: 10.1007/s00335-026-10211-w

Genes

PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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