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Article

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

Molecular cell - 3 Dec 2015

Dawicki-McKenna Jennine M, Langelier Marie-France, DeNizio Jamie E, Riccio Amanda A, Cao Connie D, Karch Kelly R, McCauley Michael, Steffen Jamin D, Black Ben E, Pascal John M

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD(+) to regulate multiple cellular processes. DNA breaks sharply elevate PARP-1 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is associated with cell death. The mechanism for tight control of the robust catalytic potential of...

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Identifiers

PMID: 26626480
DOI: 10.1016/j.molcel.2015.10.013
PMCID: PMC4712911

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