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Article

Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations.

Clinical pharmacology and therapeutics - 1 Mar 2023

Steiner Heidi E, Carrion Kelvin Carrasquillo, Giles Jason B, Lima Abiel Roche, Yee Kevin, Sun Xiaoxiao, Cavallari Larisa H, Perera Minoli A, Duconge Jorge, Karnes Jason H

Abstract excerpt

Accuracy of warfarin dose prediction algorithms may be improved by including data from diverse populations in genetic studies of dose variability. Here, we surveyed single nucleotide polymorphisms in vitamin K-related genetic pathways for association with warfarin dose requirements in two admixed Latino populations in standard-principal component adjusted and contemporary-local ancestry adjusted regression...

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Share to Anticoagulants
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Vitamin K Epoxide Reductases

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Source

Open in PubMed Open full text

Identifiers

PMID: 36321873
DOI: 10.1002/cpt.2787
PMCID: PMC9957812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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