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Article

Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans.

Blood - 2 Oct 2014

Daneshjou Roxana, Gamazon Eric R, Burkley Ben, Cavallari Larisa H, Johnson Julie A, Klein Teri E, Limdi Nita, Hillenmeyer Sara, Percha Bethany, Karczewski Konrad J, Langaee Taimour, Patel Shitalben R, Bustamante Carlos D, Altman Russ B, Perera Minoli A

Abstract excerpt

The anticoagulant warfarin has >30 million prescriptions per year in the United States. Doses can vary 20-fold between patients, and incorrect dosing can result in serious adverse events. Variation in warfarin pharmacokinetic and pharmacodynamic genes, such as CYP2C9 and VKORC1, do not fully explain the dose variability in African Americans. To identify additional genetic contributors to warfarin dose, we exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25079360
DOI: 10.1182/blood-2014-04-568436
PMCID: PMC4183989

Genes

FPGS
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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