Article
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Pharmacogenomics - 1 Mar 2012
Ramirez Andrea H, Shi Yaping, Schildcrout Jonathan S, Delaney Jessica T, Xu Hua, Oetjens Matthew T, Zuvich Rebecca L, Basford Melissa A, Bowton Erica, Jiang Min, Speltz Peter, Zink Raquel, Cowan James, Pulley Jill M, Ritchie Marylyn D, Masys Daniel R, Roden Dan M, Crawford Dana C, Denny Joshua C
Abstract excerpt
AIM: Warfarin pharmacogenomic algorithms reduce dosing error, but perform poorly in non-European-Americans. Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose. PATIENTS & METHODS: We used BioVU, the Vanderbilt EHR-linked DNA repository, to identify European-Americans (n = 1022) and African-Americans (n = 145) on stable...
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