Article
Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.
Cancer research communications - 1 Oct 2022
Ghezelayagh Talayeh S, Kohrn Brendan F, Fredrickson Jeanne, Manhardt Enna, Radke Marc R, Katz Ronit, Gray Heidi J, Urban Renata R, Pennington Kathryn P, Liao John B, Doll Kemi M, Simons Elise J, Burzawa Jennifer K, Goff Barbara A, Speiser Paul, Swisher Elizabeth M, Norquist Barbara M, Risques Rosa Ana
Abstract excerpt
Current screening methods for ovarian cancer (OC) have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultra-deep sequencing for the detection of disseminated OC cells has emerged as a promising tool, but this approach has not been tested for early-stage disease or non-serous histologies. In addition, lavages carry multiple background mutations, the significance of...
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