Article
Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue.
Gynecologic oncology - 1 Jun 2024
Pandya Deep, Tomita Shannon, Rhenals Maria Padron, Swierczek Sabina, Reid Katherine, Camacho-Vanegas Olga, Camacho Catalina, Engelman Kelsey, Polukort Stephanie, RoseFigura Jordan, Chuang Linus, Andikyan Vaagn, Cohen Samantha, Fiedler Paul, Sieber Steven, Shih Ie-Ming, Billaud Jean-Noël, Sebra Robert, Reva Boris, Dottino Peter, Martignetti John A
Abstract excerpt
OBJECTIVE: Endometrial cancer (EndoCA) is the most common gynecologic cancer and incidence and mortality rate continue to increase. Despite well-characterized knowledge of EndoCA-defining mutations, no effective diagnostic or screening tests exist. To lay the foundation for testing development, our study focused on defining the prevalence of somatic mutations present in non-cancerous uterine tissue. METHODS: We...
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