Article

Ultra-sensitive sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan

2018-11-04

Abstract excerpt

<h4>ABSTRACT</h4> High accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally-invasive body fluid samples. We demonstrate 80% sensitivity for ovarian cancer detection using ultra-accurate Duplex Sequencing to identify TP53 mutations in uterine lavage. However, in addition to tumor DNA, we also detect low f...

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Literature Corpus work: d8d421fe-3fc1-5e89-b0cc-604cf642195c
DOI: 10.1101/457291

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