Article
Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study.
PLoS medicine - 1 Dec 2016
Nair Navya, Camacho-Vanegas Olga, Rykunov Dmitry, Dashkoff Matthew, Camacho Sandra Catalina, Schumacher Cassie A, Irish Jonathan C, Harkins Timothy T, Freeman Elijah, Garcia Isaac, Pereira Elena, Kendall Sviatoslav, Belfer Rachel, Kalir Tamara, Sebra Robert, Reva Boris, Dottino Peter, Martignetti John A
Abstract excerpt
BACKGROUND: Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based analysis of endometrial cancer by The Cancer Genome Atlas (TCGA) revealed many of the molecular...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cross-Sectional Studies
- DNA, Neoplasm
- Endometrial Neoplasms
- Female
- Genome
- Humans