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Article

Detecting TP53 mutations in paired liquid and tissue biopsies from patients with high-grade serous ovarian carcinoma.

International journal of cancer - 15 Apr 2026

Widjaja Amanda Olsson, Micallef Peter, Lycke Maria, Österlund Tobias, Santamaría Manuel Luna, Lindberg Julia Hedlund, Carlsson Therese, Gyllensten Ulf, Ståhlberg Anders, Ulfenborg Benjamin, Linder Anna, Sundfeldt Karin

Abstract excerpt

High-grade serous ovarian carcinoma (HGSC) is the most lethal form of ovarian carcinoma, often diagnosed at advanced stages due to non-specific symptoms and the lack of reliable screening methods. This proof-of-concept study aimed to develop a robust TP53 mutation panel for detecting HGSC through targeted DNA sequencing in both liquid and solid biopsies. We constructed a custom TP53 gene panel and utilized a...

Topics

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Biomarkers, Tumor
Biopsy
Cystadenocarcinoma, Serous
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Ovarian Neoplasms

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41363274
DOI: 10.1002/ijc.70277
PMCID: PMC12922644

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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