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Article

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2016

Krimmel Jeffrey D, Schmitt Michael W, Harrell Maria I, Agnew Kathy J, Kennedy Scott R, Emond Mary J, Loeb Lawrence A, Swisher Elizabeth M, Risques Rosa Ana

Abstract excerpt

Current sequencing methods are error-prone, which precludes the identification of low frequency mutations for early cancer detection. Duplex sequencing is a sequencing technology that decreases errors by scoring mutations present only in both strands of DNA. Our aim was to determine whether duplex sequencing could detect extremely rare cancer cells present in peritoneal fluid from women with high-grade serous...

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Identifiers

PMID: 27152024
DOI: 10.1073/pnas.1601311113
PMCID: PMC4889384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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