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Article

ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance

10 Oct 2022

Abstract excerpt

Objective: The contribution of activating transcription factor 6α (ATF6α) in rheumatoid arthritis (RA) pathogenesis, especially on fibroblast-like synoviocytes (FLSs), has been suggested by its sensitivity to inflammatory stimulus. However, the exact role and therapeutic potential of ATF6α in RA remains to be fully elucidated. Methods: ATF6α expression was determined in joint tissues and FLS, and gain-of-function...

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PMID: 36300114
DOI: 10.3389/fimmu.2022.965708

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