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Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases

17 Feb 2020

Abstract excerpt

Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than 200 million and 20 million people, respectively. Several transcription factors have been implicated in the onset and progression of osteoarthritis, including Runx2, C/EBPβ, HIF2α, Sox4, and Sox11. Interleukin-1 β (IL-1β) leads to osteoarthritis through NF-ĸB, IκBζ, and the Zn2+-ZIP8-MTF1 axis. IL-1,...

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PMID: 32079226
DOI: 10.3390/ijms21041340

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