Article

Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapy for rheumatoid arthritis

2025-01-23

Abstract excerpt

<title>Abstract</title> <p>Background Mesenchymal stem/stromal cell (MSCs) therapy represents a potential therapeutic tool to treat RA, but loss of secretory property post delivery restricted clinical application. It has been verified that endoplasmic reticulum stress (ERS)-MSCs exhibited better inhibition on rheumatoid arthritis (RA) T follicular helper cells (Tfh) via cyclooxygenase-2 (COX2)/prostaglandin E2 (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fafe11ac-c8ac-508b-99ac-ee993ce474c6
DOI: 10.21203/rs.3.rs-5620379/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapy for rheumatoid arthritisDOI 10.21203/rs.3.rs-5620379/v1Read

ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistanceSemantic proximity Read

ATP2A3 promotes inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes via activation of the STING signaling pathwaySemantic proximity Read

Gene Expression Profiling to Unfolded Proteins Response as a Risk Modulator of Patients with Rheumatoid Arthritis.Semantic proximity Read

Characterization and role exploration of ferroptosis-related genes in osteoarthritisSemantic proximity Read

IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritisSemantic proximity Read

Transmission of ER stress response by ATF6 promotes endochondral bone growthSemantic proximity Read

Prokineticin 2 promotes endoplasmic reticulum stress in rheumatoid arthritis by potentiating IL-1β–induced inflammationSemantic proximity Read

Determining what happens to the genes FOXP3, RORγt, SOCS1, STAT3, STAT5, and SMAD3 in patients with ankylosing spondylitis who received anti-TNF therapySemantic proximity Read

Dental Follicle Mesenchymal Stem Cell-Derived Exosomes Mitigate Temporomandibular Joint Osteoarthritis in an In Vitro Model via the miR-146a-5p/Traf6/NF-κB AxisSemantic proximity Read

The Fra-1: Novel role in regulating extensive immune cell states and affecting inflammatory diseasesSemantic proximity Read

The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection ResponsesSemantic proximity Read

Molecular mechanism of ATF6 in unfolded protein response and its role in diseaseSemantic proximity Read