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Identification of putative master regulators in rheumatoid arthritis synovial fibroblasts using gene expression data and network inference

1 Oct 2020

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the synovial joints of the body. Rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) are central players in the disease pathogenesis, as they are involved in the secretion of cytokines and proteolytic enzymes, exhibit invasive traits, high rate of self-proliferation and an apoptosis-resistant phenotype. We aim at characterizing...

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PMID: 33004899
DOI: 10.1038/s41598-020-73147-4

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