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Article

ATF3 deficiency in chondrocytes alleviates osteoarthritis development

9 May 2016

Abstract excerpt

Activating transcription factor 3 (Atf3) has been implicated in the pathogenesis of various diseases, including cancer and inflammation, as well as in the regulation of cell proliferation and differentiation. However, the involvement of Atf3 in developmental skeletogenesis and joint disease has not been well studied to date. Here, we show that Atf3 is a critical mediator of osteoarthritis (OA) development through...

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PMID: 27159257
DOI: 10.1002/path.4739

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