Article
Comprehensively evaluating cis-regulatory variation in the human prostate transcriptome by using gene-level allele-specific expression.
American journal of human genetics - 4 Jun 2015
Larson Nicholas B, McDonnell Shannon, French Amy J, Fogarty Zach, Cheville John, Middha Sumit, Riska Shaun, Baheti Saurabh, Nair Asha A, Wang Liang, Schaid Daniel J, Thibodeau Stephen N
Abstract excerpt
The identification of cis-acting regulatory variation in primary tissues has the potential to elucidate the genetic basis of complex traits and further our understanding of transcriptomic diversity across cell types. Expression quantitative trait locus (eQTL) association analysis using RNA sequencing (RNA-seq) data can improve upon the detection of cis-acting regulatory variation by leveraging allele-specific...
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