Article
A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B.
Genes - 19 Oct 2022
Miranda-Miranda Estefan, Scarcella Silvana, Reynaud Enrique, Narváez-Padilla Verónica, Neira Gisela, Mera-Y-Sierra Roberto, Aguilar-Díaz Hugo, Cossio-Bayugar Raquel
Abstract excerpt
Fasciola hepatica anthelmintic resistance may be associated with the catalytic activity of xenobiotic metabolizing enzymes. The gene expression of one of these enzymes, identified as carboxylesterase B (CestB), was previously described as inducible in adult parasites under anthelmintic treatment and exhibited a single nucleotide polymorphism at position 643 that translates into a radical amino acid substitution...
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