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Article

The F204S mutation in adrenodoxin oxidoreductase drives salinomycin resistance in Eimeria tenella.

Veterinary research - 18 Dec 2024

Sun Pei, Wang Chaoyue, Xie Fujie, Chen Linlin, Zhang Yuanyuan, Tang Xinming, Hu Dandan, Gao Yang, Zhang Ning, Hao Zhenkai, Yu Yonglan, Suo Jingxia, Suo Xun, Liu Xianyong

Abstract excerpt

Salinomycin is a polyether ionophore widely used for the treatment of coccidiosis in poultry. However, the emergence of coccidia strains resistant to salinomycin presents challenges for control efforts, and the mechanisms underlying this resistance in Eimeria remain inadequately understood. In this study, 78 stable salinomycin-resistant strains were generated through experimental evolution approaches....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39696613
DOI: 10.1186/s13567-024-01431-6
PMCID: PMC11654014

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