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Unmasking the Black Box: Computational Evidence Identifying Mitochondrial ATP Synthase Subunit β as a High-Confidence Target of Glycyrrhetinic Acid Analogs Against Brugia malayi

2026-07-17

Abstract excerpt

<title>Abstract</title> Lymphatic filariasis (LF), a devastating tropical disease caused by filarial nematodes such as Brugia malayi, remains an urgent public health concern due to the microfilaricidal limitations of frontline treatments. While Kalani et al. (2013) identified compound 6a, a semi-synthetic benzyl amide analog of glycyrrhetinic acid (GA), as a highly potent in vitro macrofilaricide (IC 5...

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Literature Corpus work: 7febc1ea-8181-51d8-afee-fb4c555f2301
DOI: 10.21203/rs.3.rs-10383379/v1

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Unmasking the Black Box: Computational Evidence Identifying Mitochondrial ATP Synthase Subunit β as a High-Confidence Target of Glycyrrhetinic Acid Analogs Against Brugia malayiDOI 10.21203/rs.3.rs-10383379/v1Read

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