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Triclabendazole-Binding Pocket Identified in <em>Fasciola hepatica </em>Carboxylesterase B

2023-09-06

Abstract excerpt

The expression of the Fasciola hepatica Carboxylesterase type B (CestB) gene is induced in response to the anthelmintic triclabendazole (TCBZ), resulting in a significant increase in enzymatic specific activity. Furthermore, the amino acid sequence of CestB exhibits variations that could lead to substantial amino acid substitutions at the ligand-binding site. These substitutions have the potential to affect the in...

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Literature Corpus work
b49631c6-dabd-5c0c-b9b0-e79e29c0b57a
DOI
10.20944/preprints202309.0347.v1
Open publication

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Triclabendazole-Binding Pocket Identified in <em>Fasciola hepatica </em>Carboxylesterase BDOI 10.20944/preprints202309.0347.v1
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