Article
A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector.
Genome biology - 25 Feb 2014
Riveron Jacob M, Yunta Cristina, Ibrahim Sulaiman S, Djouaka Rousseau, Irving Helen, Menze Benjamin D, Ismail Hanafy M, Hemingway Janet, Ranson Hilary, Albert Armando, Wondji Charles S
Abstract excerpt
BACKGROUND: Metabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. However, its underlying molecular basis, crucial for successful resistance management, remains poorly characterized. RESULTS: Here, we demonstrate that the single amino acid change L119F in an upregulated glutathione S-transferase gene, GSTe2, confers high levels of metabolic resistance...
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