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Article

Functional analysis of genetic polymorphism in Wuchereria bancrofti glutathione S-transferase antioxidant gene: impact on protein structure and enzyme catalysis.

Molecular and biochemical parasitology - 1 Jan 2000

Sakthidevi Moorthy, Prabhu Prince Rajaiah, Chowdhary Swati, Hoti Sugeerappa Laxmanappa, Kaliraj Perumal

Abstract excerpt

Wuchereria bancrofti glutathione S-transferase (Wb-GST) is referred as a promising chemotherapeutic target for lymphatic filariasis. GST represents the major class of detoxifying enzymes of the tissue dwelling parasitic helminths. Though many inhibition studies were carried out for Wb-GST, understanding its genetic distribution in parasite population is necessary to develop ideal inhibitor. Our genetic...

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PMID: 24188745
DOI: 10.1016/j.molbiopara.2013.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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