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Article

An amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations.

Molecular and biochemical parasitology - 1 Nov 2012

Wilkinson Richard, Law Christopher J, Hoey Elizabeth M, Fairweather Ian, Brennan Gerard P, Trudgett Alan

Abstract excerpt

Control of fasciolosis is threatened by the development of anthelmintic resistance. Enhanced triclabendazole (TCBZ) efflux by ABC transporters such as P-glycoprotein (Pgp) has been implicated in this process. A putative full length cDNA coding for a Pgp expressed in adult Fasciola hepatica has been constructed and used to design a primer set capable of amplifying a region encoding part of the second nucleotide...

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Source

Identifiers

PMID: 22982092
DOI: 10.1016/j.molbiopara.2012.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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