Article

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

2023-11-16

Abstract excerpt

Cancer drug resistance is multi-factorial, driven by heritable (epi)genetic changes but also phenotypic plasticity. Here we dissect it by perturbing colorectal cancer patient-derived organoids longitudinally with drugs in sequence. Combining longitudinal tracking, single cell ’omics, evolutionary modelling, and machine leaning, we found that different targeted drugs select for distinct subclones, supporting ration...

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Literature Corpus work: ef9f13c7-f266-51f8-a9be-57abf596504c
DOI: 10.1101/2023.11.15.567140

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