Article
Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.
Genes, chromosomes & cancer - 1 Jan 2017
Herold Tobias, Metzeler Klaus H, Vosberg Sebastian, Hartmann Luise, Jurinovic Vindi, Opatz Sabrina, Konstandin Nikola P, Schneider Stephanie, Zellmeier Evelyn, Ksienzyk Bianka, Graf Alexander, Krebs Stefan, Blum Helmut, Cristina Sauerland Maria, Büchner Thomas, Berdel Wolfgang E, Wörmann Bernhard J, Mansmann Ulrich, Hiddemann Wolfgang, Bohlander Stefan K, Spiekermann Karsten, Greif Philipp A
Abstract excerpt
Deletions of the long arm of chromosome 9 [del(9q)] are a rare but recurring aberration in acute myeloid leukemia (AML). Del(9q) can be found as the sole abnormality or in combination with other cytogenetic aberrations such as t(8;21) and t(15;17). TLE1 and TLE4 were identified to be critical genes contained in the 9q region. We performed whole exome sequencing of 5 patients with del(9q) as the sole abnormality...
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