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Article

NUP214 fusion genes in acute leukemia (Review)

18 Jun 2014

Abstract excerpt

Nucleoporin 214 (NUP214), previously termed CAN, is required for cell cycle and nucleocytoplasmic transport. The genetic features and clinical implications of five NUP214‑associated fusion genes are described in this review. SET‑NUP214 was most frequently observed in T‑cell acute lymphoblastic leukemia (T‑ALL), concomitant with the elevated expression of HOXA cluster genes. Furthermore, the fusion transcript may...

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Identifiers

PMID: 25120641
DOI: 10.3892/ol.2014.2263

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