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Article

Tolerance to replication stress requires Dun1p kinase and activation of the electron transport chain.

Biochimica et biophysica acta. Molecular cell research - 1 Jan 2023

Nagar Shreya, Mehta Riddhi, Kaur Pritpal, Liliah Roshini T, Vancura Ales

Abstract excerpt

One of the key outcomes of activation of DNA replication checkpoint (DRC) or DNA damage checkpoint (DDC) is the increased synthesis of the deoxyribonucleoside triphosphates (dNTPs), which is a prerequisite for normal progression through the S phase and for effective DNA repair. We have recently shown that DDC increases aerobic metabolism and activates the electron transport chain (ETC) to elevate ATP production...

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Identifiers

PMID: 36283478
DOI: 10.1016/j.bbamcr.2022.119382
PMCID: PMC10329874

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