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Article

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription.

Molecular cell - 16 Jul 2026

Budinich Krista A, Yao Xinyi, Gong Chujie, Song Lele, Wang Xiaoting, Lee Michelle C, Mathias Kaeli M, Li Qinglan, Tang Sylvia, Liu Yiman, Nguyen Son C, Joyce Eric F, Li Yuanyuan, Li Haitao, Wan Liling

Abstract excerpt

Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer, yet how extrinsic factors modulate their assembly and function remains poorly understood. Gain-of-function mutations in the chromatin reader ENL ("Eleven-nineteen-leukemia") drive oncogenesis by inducing condensate formation at select target loci. Here, we demonstrate that locally produced transcripts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42285105
DOI: 10.1016/j.molcel.2026.05.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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