Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribonucleotide Reductase: A Critical Enzyme for Cancer Chemotherapy and Antiviral Agents

1 Jan 2007

Abstract excerpt

Ribonucleotide Reductase (RNR) plays a critical role in DNA synthesis, and is a well-recognized target for cancer chemotherapeutic and antiviral agents. RNR inhibition precludes DNA transcription and repair, from which results cell apoptosis. Many regulation checkpoints concerning RNR activity have been unravelled through the last two decades, with potential use to inhibit enzyme activity. This was accomplished...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Metal complexes synthesis and properties

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 18221051
DOI: 10.2174/157489207779561408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribonucleotide Reductase: A Critical Enzyme for Cancer Chemotherapy and Antiviral AgentsPMID 18221051Read ↗

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and PresentSemantic proximity Read ↗

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancerSemantic proximity Read ↗

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stressSemantic proximity Read ↗

Cancer Fighting SiRNA-RRM2 Loaded NanorobotsSemantic proximity Read ↗

Ribonucleotide reductases: amazing and confusing.Semantic proximity Read ↗

Inhibiting RRM2 to enhance the anticancer activity of chemotherapySemantic proximity Read ↗

The Enzyme Ribonucleotide Reductase: Target for Antitumor and Anti-HIV TherapySemantic proximity Read ↗

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.Semantic proximity Read ↗

Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3.Semantic proximity Read ↗

Starting a new chapter on class Ia ribonucleotide reductasesSemantic proximity Read ↗

Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein.Semantic proximity Read ↗

Novel regulators and molecular mechanisms of p53R2 and its disease relevance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.