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Article

Nucleotide-dependent formation of catalytically competent dimers from engineered monomeric ribonucleotide reductase protein R1.

The Journal of biological chemistry - 15 Apr 2005

Birgander Pernilla Larsson, Bug Stefanie, Kasrayan Alex, Dahlroth Sue-Li, Westman Mariann, Gordon Euan, Sjöberg Britt-Marie

Abstract excerpt

Each catalytic turnover by aerobic ribonucleotide reductase requires the assembly of the two proteins, R1 (alpha(2)) and R2 (beta(2)), to produce deoxyribonucleotides for DNA synthesis. The R2 protein forms a tight dimer, whereas the strength of the R1 dimer differs between organisms, being monomeric in mouse R1 and dimeric in Escherichia coli. We have used the known E. coli R1 structure as a framework for design...

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Identifiers

PMID: 15699052
DOI: 10.1074/jbc.M500565200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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