Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Treatment and sampling protocols for transgenic mutation assays.

Environmental and molecular mutagenesis - 1 Jan 2003

Heddle John A, Martus Hans-Joerg, Douglas George R

Abstract excerpt

The standard protocol for testing chemicals with the transgenic mutation assays in vivo includes a period of time between treatment and sampling to permit the mutation frequency to reach a maximum. Recent evidence has shown, however, that for some chemicals the mutant frequency can decline substantially during this period, which would reduce the sensitivity of the assay. Here we discuss alternate protocols to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Mice
Share to Mutagenicity Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Time Factors

Share to Transgenes

Source

Identifiers

PMID: 12552586
DOI: 10.1002/em.10131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Treatment and sampling protocols for transgenic mutation assays.PMID 12552586Read ↗

Treatment protocols for transgenic mutation assays in vivo.Semantic proximity Read ↗

Mutational spectra in transgenic animal research: data analysis and study design based upon the mutant or mutation frequency.Semantic proximity Read ↗

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review.Semantic proximity Read ↗

Mutation and mutation screening.Semantic proximity Read ↗

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals.Semantic proximity Read ↗

Mutation Analysis in Cultured Cells of Transgenic Rodents.Semantic proximity Read ↗

Use of generalized linear mixed models in analyzing mutant frequency data from the transgenic mouse assay.Semantic proximity Read ↗

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing.Semantic proximity Read ↗

Initial consideration for use of transgenic mutation assays in a regulatory submission.Semantic proximity Read ↗

An estimator of the mutant frequency in assays using transgenic animals.Semantic proximity Read ↗

A more efficient Big Blue protocol improves transgene rescue and accuracy in a adduct and mutation measurement.Semantic proximity Read ↗

Ethyl Methanesulfonate Treatment of Maize Pollen for Development of Segregating Mutant Populations or Targeted Mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.