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Article

Single object profiles regression analysis (SOPRA): a novel method for analyzing high-content cell-based screens.

BMC bioinformatics - 21 Oct 2022

Gurumurthy Rajendra Kumar, Pleissner Klaus-Peter, Chumduri Cindrilla, Meyer Thomas F, Mäurer André P

Abstract excerpt

BACKGROUND: High-content screening (HCS) experiments generate complex data from multiple object features for each cell within a treated population. Usually, these data are analyzed by using population-averaged values of the features of interest, increasing the amount of false positives and the need for intensive follow-up validation. Therefore, there is a strong need for novel approaches with reproducible hit...

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PMID: 36271357
DOI: 10.1186/s12859-022-04981-8
PMCID: PMC9587636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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