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Article

Chapter 17: bioimage informatics for systems pharmacology.

PLoS computational biology - 1 Apr 2013

Li Fuhai, Yin Zheng, Jin Guangxu, Zhao Hong, Wong Stephen T C

Abstract excerpt

Recent advances in automated high-resolution fluorescence microscopy and robotic handling have made the systematic and cost effective study of diverse morphological changes within a large population of cells possible under a variety of perturbations, e.g., drugs, compounds, metal catalysts, RNA interference (RNAi). Cell population-based studies deviate from conventional microscopy studies on a few cells, and...

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PMID: 23633943
DOI: 10.1371/journal.pcbi.1003043
PMCID: PMC3635992

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